Medical cannabis can be beneficial to you, promoting physical, mental, and social well-being.

Greater therapeutic efficacy through precise dosing and optimized absorption

We have a portfolio of products with high pharmaceutical quality, easy and precise dosage, fast-acting, efficient and safe, with the aim of providing well-being and improvement for different health conditions, in a simple and accessible way.

FUSIONNER™ TECHNOLOGY

The proprietary Fusionner™ technology uses a self-emulsifying system to optimize the bioavailability of cannabinoids.

Studies show an increase in absorption of up to 53%, resulting in greater pharmacokinetic predictability and therapeutic efficacy.

HOW DO I GET MY ENTOURAGE?

We’ll help you find the best specialists to get you started on your treatment. They’ll assess your medical condition and prescribe the Entourage formula best suited to your needs.

To start treatment you will need

MEDICAL CONSULTATION

ANVISA REGISTRATION AND AUTHORIZATION

GET YOUR ENTOURAGE

Access the Online Form

Click here and access the application page for authorization to import cannabis-based products.

Fill in Your Information

Enter your personal and medical details as requested on the form.

Do you have any questions? We're here to help!

Attach documentation

Have your prescription and personal identification documents ready.

Submit an Application

Revise and send. You're almost there!

Track Status

Keep an eye on the progress of your request. Need help? We're here to help!

Start the buying process

Send your prescription, Anvisa authorization and personal documents to
our specialized team, click here.

We'll take care of the purchasing process according to your medical prescription. It's as simple as that!

Keep in touch with your doctor

Regular follow-up is vital. Keep in touch with your doctor and our team of specialists.

Access the Online Form

Click here and access the application page for authorization to import cannabis-based products.

Fill in Your Information

Enter your personal and medical details as requested on the form.

Do you have any questions? We're here to help!

Attach documentation

Have your prescription and personal identification documents ready.

Submit an Application

Revise and send. You're almost there!

Track Status

Keep an eye on the progress of your application.

Need help? We're here to guide you!

Start the buying process

Send your prescription, Anvisa authorization and personal documents to
our specialized team, click here.

We'll take care of the purchasing process according to your medical prescription. It's as simple as that!

Keep in touch with your doctor

Regular follow-up is vital. Keep in touch with your doctor and our team of specialists.

If you need any further assistance during this process, Entourage Phytolab's friendly and professional team is ready to help. Your health is our priority, and we're with you every step of the way. 🌿💚

THE ENTOURAGE EFFECT IS ENTOURAGE

The Entourage Effect describes the synergistic interaction between the plant’s various compounds, such as cannabinoids and terpenes.

This interaction can enhance the biological response compared to the isolated use of a single compound, contributing to a more integrated therapeutic approach.

It can be seen that the combination of different cannabinoids, terpenes and other compounds can increase the effectiveness of the treatment, enhancing the therapeutic effects of each isolated compound.

CBD has been used to mitigate some of the unwanted psychoactive effects of THC, such as paranoia or anxiety.

Some research suggests that different combinations of cannabinoids, terpenes and other compounds can be customized to treat specific conditions, such as chronic pain, anxiety, inflammation, epilepsy and others.

The presence of the plant's various compounds may facilitate the absorption of CBD and THC, making them more bioavailable and possibly more effective.

In some cases, the compounds can work in a complementary way, where one compound improves or complements the function of the other, as is the case with some terpenes that can increase the anti-inflammatory properties of cannabinoids.

Some research suggests that using compounds together can reduce resistance to treatment over time, compared to using one compound alone.

It's important to note that although these benefits are promising, research into the Entourage Effect is still relatively new, and in 2015, the year Entourage was founded, only 3 scientific articles dealing with this topic had been published. Since then, the Entourage Effect has become the subject of a great deal of research and academic investigation around the world and continues to be a field that is still being explored. Although there are already several studies demonstrating some benefits in the interaction between the plant's compounds, a complete understanding of the Entourage Effect and its mechanisms is Entourage's commitment to offering the full therapeutic potential of cannabis in a safe and effective way.

Endocannaboid system

Discover the internal system that regulates a variety of vital functions in our body, influencing everything from our mood to our response to pain. Understand how our technology acts on this complex network of neurotransmitters and receptors and how it can impact your health and well-being.

The Endocannabinoid System (EES) is a complex network made up of receptors, enzymes, ligands and cannabinoids that plays a fundamental role in maintaining homeostasis in various biological functions, such as mood, appetite, sleep, pain and immunity. Discovered during research into THC in the 1990s, the Endocannabinoid System has been the subject of intense scientific research due to its vast therapeutic potential (Di Marzo, 1998; Mechoulam & Parker, 2013).

Entourage Phytolab, in its ongoing quest to improve health and well-being, continues to contribute innovative research and development in this promising field, with natural and evidence-based approaches.

Cannabinoid receptors

CB1 RECEPTORS: Predominant in the central nervous system, they are essential for neurological functions such as memory, learning and pain control. They have significant implications for the treatment of neurological and psychiatric disorders (Herkenham et al., 1990).
CB2 RECEPTORS: Located mainly in the immune system, they regulate inflammatory processes and offer therapeutic potential in autoimmune diseases (Klein et al., 2003).
TRPV RECEPTORS: These ion channels modulate the perception of pain and heat and are potential targets for chronic pain treatments (De Petrocellis et al., 2011).
GPR55: Often referred to as the "third cannabinoid receptor", it regulates bone density and pain modulation (Ryberg et al., 2007).
PPARs: These receptors are activated by cannabinoids and have notable implications in conditions such as diabetes and cardiovascular disease (O'Sullivan, 2007).

Endogenous Cannabinoids

These are natural molecules that act on cannabinoid receptors. They include:

Anandamide (AEA): Nicknamed the "happiness molecule", it is vital for regulating appetite, sleep and pain. Low levels of AEA have been associated with conditions such as depression (Russo, 2004).
2-Arachidonoylglycerol (2-AG): Extremely abundant, it plays a significant role in modulating the immune response (Mechoulam et al., 1998).
Noladin ether: This endogenous cannabinoid has anti-inflammatory and neuromodulatory properties and may have implications for neuroprotection (Feinberg et al., 2002).
Virodhamine: Relevant in pain regulation and immune response (Porter et al., 2002).
N-arachidonoyldopamine (NADA): Acting on CB1 receptors and TRPV1 channels, it is associated with pain regulation and neuroprotection (Huang et al., 2002).

Degradation Pathways

FAAH and MAGL are enzymes that degrade endogenous cannabinoids. Inhibiting these enzymes offers a promising avenue in the management of pain and inflammation (Piomelli, 2003).

Phytocannabinoids and Homeostasis

Phytocannabinoids, mainly THC and CBD, but also lesser-known compounds such as THCP, show intriguing interactions with the ESA. Entourage Phytolab is dedicated to exploring these interactions, developing "full-spectrum" products that work in harmony with the ESA to promote homeostasis.

Entourage effect

The synergistic combination of different cannabis compounds can amplify their therapeutic effects, making the whole plant more effective than its individual components (Ben-Shabat et al., 1998).

Therapeutic Potential

Cannabinoids have a variety of therapeutic applications, including:

THC: Recognized for its antiemetic, anxiolytic and analgesic effects (Grotenhermen, 2003).
THCV: Shows promise in appetite control and metabolic regulation (Wargent et al., 2013).
CBDA: Offers anti-inflammatory and anti-nausea properties (Bolognini et al., 2013).
CBC: Known for promoting neurogenesis and having anti-inflammatory effects (Shinjyo & Di Marzo, 2013).
CBG: exhibits antibacterial and anti-inflammatory characteristics, and can reduce intraocular pressure in glaucoma (Borrelli et al., 2013).
CBN: Can have sedative effects and help treat seizures (Cascio & Pertwee, 2014).
THCP: A recently discovered phytocannabinoid, it has been shown to be thirty times more potent than THC in binding to the CB1 receptor, opening up new avenues for research and therapeutic applications (Citti et al., 2019).

The Endocannabinoid System is one of the most complex and multifaceted biological systems, with a substantial impact on various physiological functions. Ongoing research and advances in understanding the complex interactions of the EES with endogenous, phytocannabinoid and synthetic cannabinoids have the potential to transform treatments for various chronic and debilitating conditions.

Entourage Phytolab, in its ongoing quest to improve health and well-being, continues to contribute innovative research and development in this promising field, with natural and evidence-based approaches.

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The use of medicinal cannabis is a reality and its benefits are already making a therapeutic contribution to the lives of many people around the world with different needs, providing physical, mental and social well-being.

Natural medicine providing physical, mental and social well-being.

The use of medicinal cannabis

The use of medicinal cannabis is a reality and its benefits are already making a therapeutic contribution to the lives of many people around the world with different needs, providing physical, mental and social well-being.

Natural therapy providing physical, mental and social well-being.

The use of medicinal cannabis

The use of medicinal cannabis is a reality and its benefits are already making a therapeutic contribution to the lives of many people around the world with different needs, providing physical, mental and social well-being.

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