The use of medicinal cannabis is indicated for different types of therapeutic treatments

The use of medicinal cannabis is a reality and its benefits are already making a therapeutic contribution to the lives of many people around the world with different needs, providing physical, mental and social well-being.

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for different health conditions, in a simple and accessible way.

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How to get my products

01

Revenue

To start your treatment, we will help you find the best specialists, who will help analyze your clinical condition and prescribe the prescription with the best treatment for your needs.

Contact us or our partner Cannect.

02

ANVISA AUTHORIZATION

With the prescription in hand, if it is simple, you will need authorization from Anvisa to release your product. Don't worry, we can help you with this process, just contact us.

If you prefer, see the step-by-step instructions and find out how to request authorization by clicking here.

03

GET YOUR PRODUCT

With your prescription and Anvisa authorization in hand, you can now buy your product, which has all the technology, quality and safety you need for your treatment.

On the journey to wellness and health, the right choice of doctor is crucial. That's why we're pleased to introduce Cannect, our partner that connects you to a base of doctors specializing in cannabis-based products.

  • Experts at Your Service: Cannect has a network of experienced and highly qualified doctors who specialize in prescribing cannabis-based products for various health conditions.
  • Personalized Consultation: Through Cannect, you can schedule consultations with professionals who understand your specific needs and work to provide the most appropriate treatment.
  • Evaluation and Safe Prescription: Obtaining a prescription is a delicate process. With Cannect, you are guaranteed a careful assessment and a responsible prescription, all in compliance with current regulations.
  • Support and Guidance: The Cannect team is here to help you every step of the way, from selecting a doctor to following up after your appointment.
  1. Connect with a Doctor: Explore the base of specialist doctors and choose the one that best suits your needs.
  2. Make an Appointment: You can decide the best day and time to make your appointment, either in person or online.
  3. Get Your Prescription: After a detailed assessment, the doctor will prescribe the most suitable cannabis-based product for your treatment.
  4. Receive Ongoing Support: Cannect will be with you after the consultation, ready to answer any questions and provide the necessary support.

With Cannect as our partner, we are even more empowered to help you on your health journey. Access to expert care, compassionate guidance and personalized treatment are just a few clicks away.

Ready to take the next step? Cannect is here to connect you to the care you deserve. 🌿💚

Anvisa authorizes import of medical cannabis-based products

If you already have a prescription for an Entourage product, you need to obtain authorization from ANVISA to buy it. Don't worry, our specialized team will help you obtain it quickly and easily.

We're here to help you take this important step in your treatment. Check out the step-by-step process for obtaining the necessary authorization from ANVISA.

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Access the Online Form

Click here and access the application page for authorization to import cannabis-based products.

Fill in Your Information

Enter your personal and medical details as requested on the form.

Do you have any questions? We're here to help!

Attach documentation

Have your prescription and personal identification documents ready.

Submit an Application

Revise and send. You're almost there!

Track Status

Keep an eye on the progress of your request. Need help? We're here to help!

Start the buying process

Send your prescription, Anvisa authorization and personal documents to
our specialized team, click here.

We'll take care of the purchasing process according to your medical prescription. It's as simple as that!

Keep in touch with your doctor

Regular follow-up is vital. Keep in touch with your doctor and our team of specialists.

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Access the Online Form

Click here and access the application page for authorization to import cannabis-based products.

Fill in Your Information

Enter your personal and medical details as requested on the form.

Do you have any questions? We're here to help!

Attach documentation

Have your prescription and personal identification documents ready.

Submit an Application

Revise and send. You're almost there!

Track Status

Keep an eye on the progress of your application.

Need help? We're here to guide you!

Start the buying process

Send your prescription, Anvisa authorization and personal documents to
our specialized team, click here.

We'll take care of the purchasing process according to your medical prescription. It's as simple as that!

Keep in touch with your doctor

Regular follow-up is vital. Keep in touch with your doctor and our team of specialists.

If you need any further assistance during this process, Entourage Phytolab's friendly and professional team is ready to help. Your health is our priority, and we're with you every step of the way. 🌿💚

Entourage effect

The "Entourage Effect" is a phenomenon that has been observed in several scientific studies and the most modern theories suggest that the compounds in the cannabis plant, when taken together, act synergistically, producing more effective and safer therapeutic effects compared to isolated compounds. Although there is still a need for more rigorous and controlled research to understand exactly this process, some benefits of the Entourage Effect noted in scientific publications include:

It can be seen that the combination of different cannabinoids, terpenes and other compounds can increase the effectiveness of the treatment, enhancing the therapeutic effects of each isolated compound.

CBD has been used to mitigate some of the unwanted psychoactive effects of THC, such as paranoia or anxiety.

Some research suggests that different combinations of cannabinoids, terpenes and other compounds can be customized to treat specific conditions, such as chronic pain, anxiety, inflammation, epilepsy and others.

The presence of the plant's various compounds may facilitate the absorption of CBD and THC, making them more bioavailable and possibly more effective.

In some cases, the compounds can work in a complementary way, where one compound improves or complements the function of the other, as is the case with some terpenes that can increase the anti-inflammatory properties of cannabinoids.

Some research suggests that using compounds together can reduce resistance to treatment over time, compared to using one compound alone.

It's important to note that although these benefits are promising, research into the Entourage Effect is still relatively new, and in 2015, the year Entourage was founded, only 3 scientific articles dealing with this topic had been published. Since then, the Entourage Effect has become the subject of a great deal of research and academic investigation around the world and continues to be a field that is still being explored. Although there are already several studies demonstrating some benefits in the interaction between the plant's compounds, a complete understanding of the Entourage Effect and its mechanisms is Entourage's commitment to offering the full therapeutic potential of cannabis in a safe and effective way.

Endocannaboid system

The Endocannabinoid System (EES) is a complex network made up of receptors, enzymes, ligands and cannabinoids that plays a fundamental role in maintaining homeostasis in various biological functions, such as mood, appetite, sleep, pain and immunity. Discovered during research into THC in the 1990s, the Endocannabinoid System has been the subject of intense scientific research due to its vast therapeutic potential (Di Marzo, 1998; Mechoulam & Parker, 2013).

Entourage Phytolab, in its ongoing quest to improve health and well-being, continues to contribute innovative research and development in this promising field, with natural and evidence-based approaches.

Cannabinoid receptors
  • CB1 RECEPTORS: Predominant in the central nervous system, they are essential for neurological functions such as memory, learning and pain control. They have significant implications for the treatment of neurological and psychiatric disorders (Herkenham et al., 1990).

  • CB2 RECEPTORS: Located mainly in the immune system, they regulate inflammatory processes and offer therapeutic potential in autoimmune diseases (Klein et al., 2003).

  • TRPV RECEPTORS: These ion channels modulate the perception of pain and heat and are potential targets for chronic pain treatments (De Petrocellis et al., 2011).

  • GPR55: Often referred to as the "third cannabinoid receptor", it regulates bone density and pain modulation (Ryberg et al., 2007).

  • PPARs: These receptors are activated by cannabinoids and have notable implications in conditions such as diabetes and cardiovascular disease (O'Sullivan, 2007).

 
Endogenous Cannabinoids

These are natural molecules that act on cannabinoid receptors. They include:

  • Anandamide (AEA): Nicknamed the "happiness molecule", it is vital for regulating appetite, sleep and pain. Low levels of AEA have been associated with conditions such as depression (Russo, 2004).

  • 2-Arachidonoylglycerol (2-AG): Extremely abundant, it plays a significant role in modulating the immune response (Mechoulam et al., 1998).

  • Noladin ether: This endogenous cannabinoid has anti-inflammatory and neuromodulatory properties and may have implications for neuroprotection (Feinberg et al., 2002).

  • Virodhamine: Relevant in pain regulation and immune response (Porter et al., 2002).

  • N-arachidonoyldopamine (NADA): Acting on CB1 receptors and TRPV1 channels, it is associated with pain regulation and neuroprotection (Huang et al., 2002).

 
Degradation Pathways
FAAH and MAGL are enzymes that degrade endogenous cannabinoids. Inhibiting these enzymes offers a promising avenue in the management of pain and inflammation (Piomelli, 2003).
Phytocannabinoids and Homeostasis
Phytocannabinoids, mainly THC and CBD, but also lesser-known compounds such as THCP, show intriguing interactions with the ESA. Entourage Phytolab is dedicated to exploring these interactions, developing "full-spectrum" products that work in harmony with the ESA to promote homeostasis.
Entourage effect
The synergistic combination of different cannabis compounds can amplify their therapeutic effects, making the whole plant more effective than its individual components (Ben-Shabat et al., 1998).
Therapeutic Potential

Cannabinoids have a variety of therapeutic applications, including:

  • THC: Recognized for its antiemetic, anxiolytic and analgesic effects (Grotenhermen, 2003).

  • THCV: Shows promise in appetite control and metabolic regulation (Wargent et al., 2013).

  • CBDA: Offers anti-inflammatory and anti-nausea properties (Bolognini et al., 2013).

  • CBC: Known for promoting neurogenesis and having anti-inflammatory effects (Shinjyo & Di Marzo, 2013).

  • CBG: exhibits antibacterial and anti-inflammatory characteristics, and can reduce intraocular pressure in glaucoma (Borrelli et al., 2013).

  • CBN: Can have sedative effects and help treat seizures (Cascio & Pertwee, 2014).

  • THCP: A recently discovered phytocannabinoid, it has been shown to be thirty times more potent than THC in binding to the CB1 receptor, opening up new avenues for research and therapeutic applications (Citti et al., 2019).

The Endocannabinoid System is one of the most complex and multifaceted biological systems, with a substantial impact on various physiological functions. Ongoing research and advances in understanding the complex interactions of the EES with endogenous, phytocannabinoid and synthetic cannabinoids have the potential to transform treatments for various chronic and debilitating conditions.

Entourage Phytolab, in its ongoing quest to improve health and well-being, continues to contribute innovative research and development in this promising field, with natural and evidence-based approaches.

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The use of medicinal cannabis is a reality and its benefits are already making a therapeutic contribution to the lives of many people around the world with different needs, providing physical, mental and social well-being.

Natural medicine providing physical, mental and social well-being.

The use of medicinal cannabis

The use of medicinal cannabis is a reality and its benefits are already making a therapeutic contribution to the lives of many people around the world with different needs, providing physical, mental and social well-being.

Natural therapy providing physical, mental and social well-being.

The use of medicinal cannabis

The use of medicinal cannabis is a reality and its benefits are already making a therapeutic contribution to the lives of many people around the world with different needs, providing physical, mental and social well-being.

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