Entourage highlights and applies a widely recognized principle: the Entourage Effect.

Entourage Phytolab is a Brazilian pharmaceutical company dedicated to the research and development of cannabis-based therapies, guided by science, innovation, and regulatory rigor.

Founded in 2015, the company’s mission is to expand access to safe, predictable, and evidence-based solutions, contributing to the advancement of clinical practice and to patients’ quality of life.

Using proprietary technology and data-driven development, Entourage transforms the therapeutic potential of cannabis into pharmaceutical formulations that meet the highest standards of quality and performance.

Exclusive Fusionner Technology

Groundbreaking Innovation in Cannabinoid Management

Fusionner™ technology represents a breakthrough in how cannabinoids are absorbed by the body.

Using a self-emulsifying system, it transforms the compounds into highly dispersed particles, facilitating absorption and improving their bioavailability.

The result is formulations that take effect more quickly, provide a more consistent response, and offer a more predictable experience throughout the course of treatment.

Increased absorption: potentiates therapeutic response.

Reduced Side Effects

It optimizes the delivery of the active ingredients, making the treatment more comfortable for the patient by reducing the effective dose of the treatment, thus also reducing side effects.

Greater Accessibility

More effective and accessible for a wide range of patients.
Studies and Approval: A clinical study published in the International Journal of Pharmaceutics in 2021 highlighted the effectiveness of this technology. Entourage Phytolab is in the process of seeking regulatory approval.

Integrating Fusionner into Your Practice

Fusionner promises to be a powerful tool in cannabinoid therapy. Its precision and effectiveness can bring real benefits to your patients.

For detailed information, clinical research and how to integrate Fusionner into your practice,
speak to one of our experts or download the full white paper.

THE CLINICAL POTENTIAL OF CANNABIS

The endocannabinoid system (ECS) is an intracellular signaling system that regulates a variety of physiological functions, including appetite, pain, inflammation and mood.

The ESA is made up of various receptors, the two best known of which are the type 1 cannabinoid receptors (CB1) and the type 2 cannabinoid receptors (CB2).

CB1s are mainly located in the central nervous system, while CB2s are mainly located in the immune system.

Cannabinoids

Cannabinoids are chemical compounds that interact with the body’s endocannabinoid system. They can be classified as endocannabinoids, which are naturally produced by the body, or phytocannabinoids, which are found in the cannabis plant.

Cannabis contains more than 100 cannabinoids, the best known of which are THC, CBD, and CBN. THC is responsible for the psychotropic effects. CBD is psychoactive but not psychotropic, and is associated with various therapeutic potentials. CBN, on the other hand, is a cannabinoid formed through the breakdown of THC, usually due to exposure to oxygen.

Entourage effect

The entourage effect is the phenomenon in which the different compounds in cannabis work together to produce more powerful therapeutic effects than any of the compounds alone. Researchers believe it has the potential to revolutionize the treatment of a variety of medical conditions.

The Entourage Effect: A Promising Frontier in Cannabinoid Medicine

The "Entourage Effect" is a concept that suggests that the cannabinoids and terpenes of the cannabis plant, when combined, have a greater therapeutic effect than when administered alone. The synergy between these substances could be vital in maximizing the therapeutic benefits of cannabis "The Entourage Effect: Synergy Between Cannabinoids and Terpenes".

Potential Mechanisms of Action of the Entourage Effect

The entourage effect is backed by growing scientific evidence suggesting various mechanisms of action:

Synergistic Receptor Binding: Cannabinoids such as THC and CBD, along with terpenes, can bind to different receptors, such as CB1, CB2, TRPV, and GPR55, producing synergistic effects (Pertwee, 2008; Gertsch et al., 2008; Ryberg et al., 2007).
Enzyme Modulation: Interaction with enzymes can lead to anti-inflammatory, antioxidant and neuroprotective effects. Izzo et al., 2009.
Increased Blood-Brain Barrier Permeability: This property can facilitate the entry of therapeutic compounds into the brain, opening up new avenues for the treatment of neurological conditions.

Practical Application and Entourage Phytolab Full Spectrum Extracts

Entourage Phytolab's full spectrum extracts enhance the entourage effect, exploiting the chemical complexity of the cannabis plant to obtain optimized therapeutic benefits. "Cannabidiol and the Entourage Effect: A Review of the Literature". This approach could unlock new possibilities for more effective and versatile treatments by harnessing the potential of the entourage effect. In addition, studies have shown that CBD-rich extracts derived from cannabis have potential clinical benefits in the treatment of treatment-resistant epilepsy, pointing to the relevance of the entourage effect "Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis".

The Entourage Effect is an exciting area of research, showing great promise in optimizing the therapeutic benefits of cannabis. Entourage Phytolab is at the forefront of this field, exploring how the entourage effect can be harnessed for new treatments "The Entourage Effect: Cannabis and Its Cannabinoids, Terpenes, and Flavonoids".

We are committed to developing new treatments that help people live better lives. We believe that cannabis has the potential to revolutionize the treatment of a variety of health conditions.

PROPERTIES, MECHANISMS AND POTENTIAL TREATMENTS

Mechanism of Action:
THC binds to CB1 receptors located in the central nervous system and gastrointestinal tract, reducing nausea and vomiting.

Potential Treatment:
Chemotherapy, post-operative.

Mechanism of Action:
THC stimulates CB1 receptors, improving appetite and the pleasure of eating.

Potential Treatment:
Wasting Syndrome, AIDS, anorexia nervosa.

Mechanism of Action:
THC and CBD interact with CB1, CB2 and TRPV receptors, modulating the perception of pain. In addition, they act synergistically with opioids.

Potential Treatment:
Chronic pain, fibromyalgia, osteoarthritis, rheumatoid arthritis, cancer pain, neuropathic pain.

Mechanism of Action:
CBD and THC reduce muscle spasticity by acting on CB1, CB2 and TRPV receptors.

Potential Treatment:
Multiple Sclerosis, Spinal Cord Injury.

Mechanism of Action:
CBD modulates ion channels and GPR55 receptors, showing a protective effect on nerve cells.

Potential Treatment:
Various types of epilepsy, including resistant forms.

Mechanism of Action:
THC and CBD act on CB1, CB2 and TRPV receptors, affecting cell proliferation and inducing apoptosis.

Potential Treatment:
Various types of cancer.

Mechanism of Action:
CBD modulates ion channels and GPR55 receptors, showing a protective effect on nerve cells.

Potential Treatment:
Chronic inflammation, dermatitis, psoriasis, Crohn's, Colitis.

Mechanism of Action:
CBD has antioxidant, anti-inflammatory action, and acts on CB1, CB2, TRPV.

Potential Treatment:
Alzheimer's, Parkinson's, Amyotrophic Lateral Sclerosis.

Mechanism of Action:
THC modulates CB1 receptors, affecting mood, anxiety and depression.

Potential Treatment:
Anxiety disorders, depression, post-traumatic stress.

Mechanism of Action:
Cannabinoids have effects on glucose metabolism, lipids through action on CB1, CB2, TRPV, GPR55 receptors.

Potential Treatment:
Type 1 and 2 diabetes, obesity.

Mechanism of Action:
THC and CBD act on CB1, CB2 receptors, reducing intraocular pressure.

Potential Treatment:
Glaucoma.

Mechanism of Action:
CBD has vasodilator effects, acts on CB1, CB2, TRPV, modulating blood pressure.

Potential Treatment:
Hypertension, atherosclerosis.